What is the Ginsenoside Rd?

Ginsenoside Rd is , while it's Molecular Formula is C48H82O18. Ginsenoside RD has been shown to attenuate tau protein phosphorylation via the PI3K/AKT/GSK-3ß pathway after forebrain ischemia. This could be used to counter the risk of developing post-stroke dementia.

What is the CAS number for Ginsenoside Rd?

The CAS number of Ginsenoside Rd is 52705-93-8.

What is Ginsenoside Rd (52705-93-8) used for?

Ginsenosides are pharmacologically active natural constituents of ginseng and other plants of the genus Panax. Structurally, they are steroid glycosides derived from the triterpene squalene. Ginsenoside Rd is a protopanaxadiol which is more abundant in some Panax species (e.g., P. quinquefolium) than others. This ginsenoside has diverse in vitro and in vivo effects, including cardioprotective, neuroprotective, and anti-inflammatory actions. Notably, ginsenoside Rd is converted to other ginsenosides in response to steaming or heating plant materials, leading to loss of these activities.InChI:InChI=1/C48H82O18/c1-21(2)15-22(3)17-48(8,66-43-40(60)37(57)34(54)28(19-50)62-43)24-11-13-47(7)23-9-10-30-45(4,5)31(12-14-46(30,6)25(23)16-26(52)32(24)47)64-44-41(38(58)35(55)29(20-51)63-44)65-42-39(59)36(56)33(53)27(18-49)61-42/h15,22-44,49-60H,9-14,16-20H2,1-8H3/t22?,23?,24-,25?,26-,27+,28+,29+,30?,31?,32+,33+,34+,35+,36-,37-,38-,39+,40+,41+,42-,43-,44-,46+,47+,48-/m0/s1

What is the Ginsenoside Rd?

Ginsenoside Rd is , while it's Molecular Formula is C48H82O18. Ginsenoside RD has been shown to attenuate tau protein phosphorylation via the PI3K/AKT/GSK-3β pathway after forebrain ischemia. This could be used to counter the risk of developing post-stroke dementia.

What is the CAS number for Ginsenoside Rd?

The CAS number of Ginsenoside Rd is 52705-93-8.

What is Ginsenoside Rd (52705-93-8) used for?

Ginsenosides are pharmacologically active natural constituents of ginseng and other plants of the genus Panax. Structurally, they are steroid glycosides derived from the triterpene squalene. Ginsenoside Rd is a protopanaxadiol which is more abundant in some Panax species (e.g., P. quinquefolium) than others. This ginsenoside has diverse in vitro and in vivo effects, including cardioprotective, neuroprotective, and anti-inflammatory actions. Notably, ginsenoside Rd is converted to other ginsenosides in response to steaming or heating plant materials, leading to loss of these activities.InChI:InChI=1/C48H82O18/c1-21(2)15-22(3)17-48(8,66-43-40(60)37(57)34(54)28(19-50)62-43)24-11-13-47(7)23-9-10-30-45(4,5)31(12-14-46(30,6)25(23)16-26(52)32(24)47)64-44-41(38(58)35(55)29(20-51)63-44)65-42-39(59)36(56)33(53)27(18-49)61-42/h15,22-44,49-60H,9-14,16-20H2,1-8H3/t22?,23?,24-,25?,26-,27+,28+,29+,30?,31?,32+,33+,34+,35+,36-,37-,38-,39+,40+,41+,42-,43-,44-,46+,47+,48-/m0/s1

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Molecular Formula: C48H82O18
Molecular Weight: 947.168
Vapor Pressure: 0mmHg at 25°C
Melting Point: 204～206℃
Refractive Index: 1.61
Boiling Point: 1020.4 °C at 760 mmHg
PKA: 12.85±0.70(Predicted)
Flash Point: 570.9 °C
PSA： 298.14000
Density: 1.37 g/cm³
LogP: -0.02680

Ginsenoside Rd(Cas 52705-93-8) Usage

InChI:InChI=1/C48H82O18/c1-21(2)15-22(3)17-48(8,66-43-40(60)37(57)34(54)28(19-50)62-43)24-11-13-47(7)23-9-10-30-45(4,5)31(12-14-46(30,6)25(23)16-26(52)32(24)47)64-44-41(38(58)35(55)29(20-51)63-44)65-42-39(59)36(56)33(53)27(18-49)61-42/h15,22-44,49-60H,9-14,16-20H2,1-8H3/t22?,23?,24-,25?,26-,27+,28+,29+,30?,31?,32+,33+,34+,35+,36-,37-,38-,39+,40+,41+,42-,43-,44-,46+,47+,48-/m0/s1

52705-93-8 Relevant articles

A novel ginsenoside-hydrolyzing enzyme from Penicillium oxalicum and its application in ginsenoside Rd production

Gao, Juan,Hu, Yanbo,Ji, Li,Wang, Nan,Wang, Jiao,Tai, Guihua,Zhou, Yifa

, p. 305 - 312 (2013)

The fungus Penicillum oxalicum can selec...

Overexpression and characterization of a glucose-tolerant β-glucosidase from Thermotoga thermarum DSM 5069T with high catalytic efficiency of ginsenoside Rb1 to Rd

Zhao, Linguo,Xie, Jingcong,Zhang, Xuesong,Cao, Fuliang,Pei, Jianjun

, p. 62 - 69 (2013)

The β-glucosidase gene Tt-bgl from Therm...

Biotransformation of the principal ginsenosides of Panax ginseng into minor glycosides through the action of bacterium Paenibacillus sp. BG134

Ten,Chae,Yoo

, (2014)

The bacterium Paenibacillus sp. BG134 wa...

Two key amino acids variant of α-l-arabinofuranosidase from bacillus subtilis str. 168 with altered activity for selective conversion ginsenoside rc to rd

Guo, Zi Yu,Luo, Zhi Yong,Tan, Shi Quan,Tian, Liang Yu,Weng, Pei,Zhang, Bian Ling,Zhang, Ru

, (2021/06/16)

α-L-arabinofuranosidase is a subfamily o...

Rational design of a β-glycosidase with high regiospecificity for triterpenoid tailoring

Park, Sang Jin,Choi, Jung Min,Kyeong, Hyun-Ho,Kim, Song-Gun,Kim, Hak-Sung

, p. 854 - 860 (2015/03/30)

Triterpenoids with desired glycosylation...

Transformation of ginsenoside Rc into (20S)-Rg3 by the bacterium leuconostoc sp. BG78

Ten,Chae,Yoo

, p. 562 - 564 (2014/08/18)

52705-93-8 Process route

: ginsenoside Rc

: 14197-60-5,38243-03-7,126252-51-5
ginsenoside Rg₃

: 52705-93-8
ginsenoside Rd

Conditions

Conditions	Yield
With Bacterium Leuconostoc sp. BG₇₈; In aq. phosphate buffer; at 37 ℃; pH=7; Microbiological reaction;

: 41753-43-9,132929-86-3
Ginsenoside Rb₁

: 62025-49-4
ginsenoside F₂

: 52705-93-8
ginsenoside Rd

Conditions

Conditions	Yield
With recombinant β-glycosidase from Microbacterium sp. Gsoil 167, wild-type; for 24h; Enzymatic reaction;

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